ParkinsonCanadaV1, Main, Exploration, bibRecord, 004585

Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism

Identifieur interne : 004585 ( Main/Exploration ); précédent : 004584; suivant : 004586

Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism

Auteurs : Baltazar Gomez-Mancilla [Canada] ; René Boucher [Canada] ; René Bédard [Canada]

Source :

Movement Disorders [ 0885-3185 ] ; 1992.

RBID : ISTEX:F661EFAC21CA0B712BC4178F12C2BE5F499D6610

Descripteurs français

Wicri :
- topic : Singe.

English descriptors

KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Antiparkinson Agents (therapeutic use), CY 208‐243, D1 agonist, D2 agonist, Dopamine Agents (therapeutic use), Dose-Response Relationship, Drug, Drug Therapy, Combination, Electromyography, Ergolines (therapeutic use), Female, Indoles (therapeutic use), Injections, Subcutaneous, LY 171555, MPTP, Macaca fascicularis, Monkey, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (drug therapy), Parkinsonism, Phenanthridines (therapeutic use), Quinpirole, Tremor, Tremor (chemically induced), Tremor (drug therapy).
MESH :
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agents, Ergolines, Indoles, Phenanthridines.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Quinpirole.
- chemically induced : Parkinson Disease, Secondary, Tremor.
- drug therapy : Parkinson Disease, Secondary, Tremor.
- Animals, Dose-Response Relationship, Drug, Drug Therapy, Combination, Electromyography, Female, Injections, Subcutaneous, Macaca fascicularis.

Abstract

The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208‐243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest termor in the limbs. The D2 agonist suppressed rest tremor in a dose‐dependent fashion. The D1 agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.

Url:

https://api-v5.istex.fr/document/F661EFAC21CA0B712BC4178F12C2BE5F499D6610/fulltext/pdf

DOI: 10.1002/mds.870070108

Affiliations:

Canada

Le document en format XML

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<term>CY 208‐243</term>
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<term>Dopamine Agents (therapeutic use)</term>
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<term>Injections, Subcutaneous</term>
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<term>Parkinson Disease, Secondary (drug therapy)</term>
<term>Parkinsonism</term>
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<term>Tremor (chemically induced)</term>
<term>Tremor (drug therapy)</term>
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<front><div type="abstract" xml:lang="en">The antitremor effect of the D2 agonist LY 171555 and of the D1 agonist CY 208‐243 alone and in combination was tested in a monkey previously rendered parkinsonian by MPTP and displaying exceptionally a rest termor in the limbs. The D2 agonist suppressed rest tremor in a dose‐dependent fashion. The D1 agonist by itself had no effect but it potentiated the effect of a small dose of LY 171555.</div>
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La maladie de Parkinson au Canada (serveur d'exploration)

Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism

Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonism

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.